منابع مشابه
Is schizophrenia linked to chromosome 1q?
Chromosome 1q? Levinson et al. (1) reported the results of a meta-analysis of families showing no major schizophrenia locus on chromosome 1q. These results, based on a multicenter study of affected sibling pairs (ASPs), are in striking contrast to findings of several recent papers reporting susceptibility loci on 1q in extended families. Significant linkage (LOD 6.5) at 1q21-22 was detected in ...
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Asthma is an inflammatory disorder of the airways associated with increased airway responsiveness and airway remodeling. Several genome wide association studies (GWAS) and non-GWAS studies have demonstrated a strong genetic linkage of chromosome 17q21 genes with asthma in populations of diverse ethnic backgrounds. In particular, SNPs in the 17q21 region are found within a large linkage disequil...
متن کاملNo major schizophrenia locus detected on chromosome 1q in a large multicenter sample.
Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of Euro...
متن کاملChromosome 2p14 Is Linked to Susceptibility to Leprosy
BACKGROUND A genetic component to the etiology of leprosy is well recognized but the mechanism of inheritance and the genes involved are yet to be fully established. METHODOLOGY A genome-wide single nucleotide polymorphism (SNP) based linkage analysis was carried out using 23 pedigrees, each with 3 to 7 family members affected by leprosy. Multipoint parametric and non-parametric linkage analy...
متن کاملGetting a Clue from 1q: Gain of Chromosome 1q in Cancer
Cytogenetic abnormalities including the gain and loss of chromosomes play an important role in oncogenesis. Aberrations involving chromosome 1 are one of the most common anomalies reported among human neoplasms and have been observed in both solid tumors and hematological malignancies. This review highlights the prognostic import of cytogenetic abnormalities involving 1q in childhood cancers an...
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ژورنال
عنوان ژورنال: Science
سال: 2002
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1076508